At the age of eight he was introduced into the world of music in the Escuela de Bellas Artes (School of Fine Arts) of his native city, later furthering his musical studies in Mexico City. In 1950, at the age of fifteen, he composed his first melody titled Nunca en el Mundo (Never in the World), of which twenty-one versions in different languages have been recorded to date. The following year he began his professional career as a pianist.
In 1957 he was signed as musical director by the Mexican branch of CBS International and as Musical Promoter for EMI, becoming the next year the pianist of Latin American artists such as Pedro Vargas, Lucho Gatica and Raphael.
In 1959, an executive of RCA Victor urged him to record his first album of love songs, which he named Mi Primera Grabación (My First Record).
In 1965 he won the first place of the Festival de la Canción (Song Festival) in Miami with the song Cuando Estoy Contigo (When I’m With You).
In 1970, his song “Somos Novios” was translated into English by Sid Wayne, composer for Elvis Presley. The English version, “It’s Impossible”, was performed by Perry Como and was nominated for a Grammy.
In 1978 he won the first place of the Mallorca Festival in Spain, with the song Señor Amor (Mister Love). In 1982, the song Corazón Amigo (Heart Friend), was honored in the Yamaha Festival. In 1993 Billboard magazine gave him an award for his excellent musical career.
In 2011, Manzanero became President of and one of the main directors of the Asociación Nacional de Autores y Compositores (Mexican National Association of Authors and Composers). He also served as Vice President of the association From 1982 through 2011. His work in defense of copyright laws has strengthened this organization and has given it international acclaim.